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Table 3. The team of surgeons, anaesthesiologists and intensivists, as well as all the protocols remained unchanged during the time period in review.
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The labels for simvastatin, Vytorin, and Simcor were also revised to include new dosing recommendations when these drugs are used with certain medicines that interact with simvastatin to increase the level of simvastatin in the body. In the first stage, a linear regression model was fitted with co-variates, stepwise variables corresponding to invention time periods to examine the FDA warnings and the impact of the Health Canada warning letter. The FDA advised healthcare professionals to switch patients for whom the mg dose of simvastatin is not sufficient to other cholesterol-lowering treatments and to switch patients who need to be started on a drug that interacts with simvastatin to another statin with less potential for interaction. Cam Patterson, MD, a cardiologist at the University of North Carolina at Chapel Hill, noted that most patients who are taking simvastatin are not taking the mg dose.
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