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Levy, RPh Q: These serious events may occur without warning. Naprelan is usually dosed once daily, and it is a controlled release tablet while Naprosyn is dosed more often.

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You may get some of the following effects. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.

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Correct volume status in dehydrated or hypovolemic patients prior to initiating naproxen sodium. Don't use this medicine just before or after having heart bypass surgery. Patients at greatest risk of this reaction are those with impaired renal function, dehydration, hypovolemia, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors or ARBs, and the elderly.

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